omega-3 fatty acids are essential fats that plays a crucial role in maintaining

cardiovascular health

reducing inflammation

supporting neurological function

increasing longevity

because the human body cannot produce enough omega-3 on its own, they must be obtained from diet or supplementation

types of omega-3

alpha-linolenic acid

  • plant-derived
  • essential for human body, body cannot synthesize it

eicosapentaenoic acid

  • marine-derived, microalgae is the only practical source, fish eat microalgae to get epa
  • body can convert ~5% from ala
  • controls inflammation, blood clotting, vascular tone, mood regulation

docosahexaenoic acid

  • marine-derived, microalgae is the only practical source, fish eat microalgae to get dha
  • body can convert ~2% from ala
  • needed for brain, eyes, nervous system, sperm and embryo development

chemical properties

solubility: insoluble in water; soluble in organic solvents and fats

structure: polyunsaturated chains with multiple cis double bonds

therapeutic activity

cardiovascular health

  • reduces triglycerides by up to 30% and lowers risk of sudden cardiac death
  • regulating cholesterol
  • and reducing blood pressure

neuroprotection & mood regulation

  • supporting cognitive function and vision
  • reduced risk of depression, anxiety
  • protecting against age-related cognitive decline

longevity: higher blood omega-3 index is associated with living 4–5 years longer on average due to lower telomere shortening

anti-inflammatory

recommended daily intake

category epa, mg/day dha, mg/day ala, g/day notes
general health ~250 ~250 women: 1.1, men: 1.6 minimum for adults to support cardiovascular and brain health
longevity ~500 ~500 women: 1.1, men: 1.6 longevity, cognition, and reduced inflammation
therapeutic 1000 1000 women: 1.1 for high triglycerides, mood disorders, chronic inflammation under medical supervision

food sources

food / source ala, mg epa, mg dha, mg total, mg notes
flaxseed, 10 g ~2300 0 0 ~2300 top concentrated plant source
chia seeds, 10 g ~1750 0 0 ~1750 excellent
perilla oil, 10 g ~9000 0 0 ~9000 oil, very high
hemp seeds, 10 g ~2000 0 0 ~2000 balanced omega-6:3 ratio
walnut, 100 g ~2500 0 0 ~2500 also rich in polyphenols
sacha inchi seeds, 100 g ~7000 0 0 ~7000 tropical nut, very rich
fresh purslane, 100 g ~350 0 0 ~350 top leafy green source
diplazium fronds, 100 g ~300 0 0 ~300 available in southeast asia
amaranth leaves, 100 g ~250 0 0 ~250 common leafy green
spinach, 100 g ~150 0 0 ~150 modest
salmon, 100 g ~0 ~500 ~1700 ~2200 very rich in dha
mackerel, 100 g ~0 ~400 ~700 ~1100 one of the top fish sources
sardines, 100 g ~0 ~500 ~900 ~1400 small fish, lower mercury
trout, 100 g ~0 ~150 ~600 ~750 cold-water freshwater fish
schizochytrium , 1 g ~0 ~10 ~300 ~300 dominant dha producer, 40–50% of lipids as dha
aurantiochytrium, 1 g ~0 ~5 ~300 ~300 similar to schizochytrium, high dha
nannochloropsis, 1 g ~0 ~30 ~0 ~30 very rich in epa, no dha

conclusion

for health and longevity, prioritize marine or algal sources of epa and dha, while using plant foods for ala. evolutionarily, our brains and eyes expanded in coastal and riverine environments where fish and shellfish provided a steady stream of these epa/dha fats. so epa/dha from plankton → small fish → larger fish → humans, shaped our cognitive evolution and longevity.

eating 2–3 servings of fatty fish per week, or taking high-quality algal/fish oil supplements, ensures optimal intake

omega-3 are not just nutrients — they're long-term investments in vitality, resilience, and extended healthy lifespan

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