cycloergostanol

cycloergostanol is a complex steroid derivative belonging to the class of phytosterols or ergostane-type steroids, often found in fungi, lichens, and some medicinal plants. structurally related to ergosterol, cycloergostanol compounds have been studied for their potential anticancer, antimicrobial, and anti-inflammatory activities. they feature a cyclopropane ring and multiple methyl substitutions in their sterol backbone.

molecular weight: varies depending on side chains; typical derivatives ~470–490 g/mol
structure: tetracyclic sterol nucleus with cyclopropyl or methylated side groups
melting point: estimated range 160–190°C
solubility: lipid-soluble; insoluble in water
chemical formula: C₃₀H₅₀O (for common cycloergostanol acetate derivatives)

cycloergostanol derivatives exhibit potential anticancer effects by inducing apoptosis and inhibiting cell proliferation in tumor cells.
they show anti-inflammatory activity, particularly by downregulating pro-inflammatory cytokines.
some compounds have demonstrated neuroprotective potential in preclinical studies.
used as lead structures for drug discovery in steroid-based pharmacology.
their bioactivity depends on structural variations like acetate esters or oxidation states.

certain cycloergostanol derivatives display broad-spectrum antimicrobial activity against bacteria, fungi, and even some protozoa.
mechanisms include membrane disruption and enzyme inhibition.
research highlights:
bacteria:
- mycobacterium tuberculosis research link
- staphylococcus aureus research link
fungi:
- candida albicans research link

Cyber